Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles

Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel not only in their non‐toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano‐bio interactions and discover new connections in nanoscale research.     

Triple-Layered Metal-Organic Framework Hybrid for Tandem Response-Driven Enhanced Chemotherapy

The precise release of drugs is essential to improve cancer therapeutic efficacy. In this work, a tandem responsive strategy was developed based on a triple-layered metal-organic framework (MOF) hybrid. The MOF nanoprobe was stepwise fabricated with a telomerase-responsive inner, a pH-sensitive MOF filling and H₂O₂-responsive coordination complex shell of Fe³⁺ and eigallocatechin gallate (EGCG). In the tumor microenvironment, the shell was dissociated by endogenous H₂O₂ and simultaneously produced highly reactive hydroxyl radicals by a Fenton reaction. Meanwhile, the released EGCG could downregulate the expression of P-glycoprotein responsible for drug resistance. After the dissociation of the framework by protons, telomerase could trigger the release of the drug from the DNA duplex on the exposed inner shell. By integrating confined drug release, inhibited efflux pump and chemodynamic therapy, the all-in-one chemotherapy strategy was identified with enhanced therapeutic efficacy in drug-resistant cancer cells.     

2D/3D ZnIn2S4/TiO2复合物的原位构筑及其提高的光催化性能

通过高温煅烧和油浴的方法构筑二维/三维(2D/3D) ZnIn₂S₄/TiO₂异质结, 应用于光催化降解罗丹明B (RhB)和四环素(TC), 来研究异质结的构筑对TiO₂可见光响应范围和光生载流子对分离效率的影响. 结果表明, TiO₂维持了MOFs的形貌, 显示窄的可见光响应范围和高的光生电荷复合率, 与ZnIn₂S₄纳米片复合后, TiO₂的比表面积增大, 光催化活性位点增多. 带隙宽度也由TiO₂的3.23 eV减小到ZnIn₂S₄/TiO₂-II的2.52 eV, 从而获得了更宽的可见光响应范围. 能带结构表明ZnIn₂S₄/TiO₂是type II型异质结, 提高了光生载流子对的分离与转移效率. 在可见光照射下, ZnIn₂S₄/TiO₂-II显示了最高的RhB光催化降解效率(93%), 分别是TiO₂和ZnIn₂S₄的18和2倍. 同时, ZnIn₂S₄/TiO₂-II也显示出比TiO₂和ZnIn₂S₄更高的TC降解效率(90%). 循环实验表明ZnIn₂S₄/TiO₂-II能保持良好的稳定性, 经5次循环实验后仍能降解83%的RhB. 研究表明基于MOFs衍生的TiO₂构筑2D/3D ZnIn₂S₄/TiO₂异质结是提高TiO₂光催化性能的一条有效途径.     

An Extremal Problem Arising in the Dynamics of Two-Phase Materials That Directly Reveals Information about the Internal Geometry

In two-phase materials, each phase having a non-local response in time, it has been found that for some driving fields the response somehow untangles at specific times, and allows one to directly infer useful information about the geometry of the material, such as the volume fractions of the phases. Motivated by this, and to obtain an algorithm for designing appropriate driving fields, we find approximate, measure independent, linear relations between the values that Markov functions take at a given set of possibly complex points, not belonging to the interval [-1,1] where the measure is supported. The problem is reduced to simply one of polynomial approximation of a given function on the interval [-1,1] and, to simplify the analysis, Chebyshev approximation is used. This allows one to obtain explicit estimates of the error of the approximation, in terms of the number of points and the minimum distance of the points to the interval [-1,1]. Assuming this minimum distance is bounded below by a number greater than 1/2, the error converges exponentially to zero as the number of points is increased. Approximate linear relations are also obtained that incorporate a set of moments of the measure. In the context of the motivating problem, the analysis also yields bounds on the response at any particular time for any driving field, and allows one to estimate the response at a given frequency using an appropriately designed driving field that effectively is turned on only for a fixed interval of time. The approximation extends directly to Markov-type functions with a positive semidefinite operator valued measure, and this has applications to determining the shape of an inclusion in a body from boundary flux measurements at a specific time, when the time-dependent boundary potentials are suitably tailored. © 2022 Wiley Periodicals, Inc.     

Estimation of IIR Systems with Binary-Valued Observations*

Estimation and control problems with binary-valued observations exist widely in practical systems. However, most of the related works are devoted to finite impulse response (FIR for short) systems, and the theoretical problem of infinite impulse response (IIR for short) systems has been less explored. To study the estimation problems of IIR systems with binary-valued observations, the authors introduce a projected recursive estimation algorithm and analyse its global convergence properties, by using the stochastic Lyapunov function methods and the limit theory on double array martingales. It is shown that the estimation algorithm has similar convergence results as those for FIR systems under a weakest possible non-persistent excitation condition. Moreover, the upper bound for the accumulated regret of adaptive prediction is also established without resorting to any excitation condition.     

基于薄膜编码超表面的宽频超薄声散射体

该文提出了一种基于薄膜编码超表面的宽频超薄声散射体。利用附加质量块的薄膜和空气腔组成的薄膜结构构建了反射声波相位差接近180°的两种共振单元。将两种共振单元按照一定的顺序进行排列,可以组成深亚波长尺寸下的声学超表面。所构建的声学超表面可以产生宽频有效的散射声场。通过有限元仿真软件对多个频率的近场散射声场分布、远场声指向性和扩散系数进行了仿真计算,仿真结果显示,该散射体可以高效地散射入射声波,并且散射效果在一定的频率范围内是宽频有效的。     

基于等效密度流体模型的地声参数分析

目前的地声参数反演多采用液态海底模型,但是实际海底为多孔弹性海底。该文在等效密度流体模型基础上,通过计算液态海底和多孔弹性海底的反射系数及传播损失,给出了等效密度流体模型和液态海底模型的等效性分析。数值仿真结果表明在低频情况下,多孔弹性海底给出的快纵波声速与等效密度流体模型给出的声速以及等效密度流体的实部与真实的海底密度基本一致。将等效密度流体模型近似看作液态海底模型进行反射系数和传播损失计算,在小掠射角和远距离时,计算结果表明与多孔弹性海底计算结果具有较好一致性,从而以此为依据确定海底为液态,进行地声参数反演。     

新型列车侧墙内装板声学分析、优化及应用*

为了开发与应用新型列车车体降噪内装结构,基于混合FE-SEA法对轨道车辆用新型橡胶泡棉夹芯板进行隔声与声辐射预测建模,并进行了试验验证,进而利用该模型分析了橡胶泡棉孔隙率与芯皮厚度比对其隔声性能、声辐射性能的影响规律,并通过敷设阻尼层优化了其声学性能。最后,在侧墙组合结构的声学设计中评价了其实际应用效果。结果表明：随着孔隙率的逐步下降,橡胶泡棉夹芯板隔声量上升趋势较为明显,而辐射声功率持续降低;随着芯皮厚度比的逐步提高,夹芯板隔声量呈略微上升趋势,辐射声功率则相应降低。在远离声源一侧的橡胶泡棉蒙皮外侧敷设阻尼层的效果最优,优化后夹芯板计权隔声量提高0.7dB,总声功率级降低0.7dB;相较于传统木质胶合板和铝蜂窝板,橡胶泡棉夹芯板相较于传统内装板材在结构隔声设计中具有轻量化优势。     

氧化铟锡薄膜的磁感应热声分析

基于优良导体在磁场下的涡流效应理论和固体的热声效应理论,建立了氧化铟锡(ITO)导电薄膜磁-热-声效应的理论模型,推导了导电薄膜热致发声的温度振荡和输出声压表达式。对有基底的ITO导电膜进行了磁场下的热声理论计算和实验测试,结果表明：薄膜的温度振荡值随频率呈上升趋势,与电-热-声模型相比趋势相反;薄膜声压的理论值与实验值在频域内的变化趋势基本吻合,验证了理论模型的正确性。进而,根据磁-热-声的理论模型,分析了线圈相关参数对薄膜声压级的影响,结果表明：薄膜声压级随着线圈匝数的增加而增大,随着薄膜与线圈中心距离的增加而减小,随着线圈半径的增加而减小。文中的研究结果拓展了导电薄膜在扬声器等领域的应用。